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CS-W001157 4
Total: USD 88.00

1-Benzoylpiperazine hydrochloride

  • CAS No. 56227-55-5

  • Cat. No. CS-M1666
  • Purity≥98%
  • MDL No.MFCD00459578

*For research and further manufacturing use only, not for direct human use.

1-Benzoylpiperazine hydrochloride|CS-M1666

Structure of 56227-55-5

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General Information

  • CAS No. 56227-55-5
  • Cat. No. CS-M1666
  • Purity ≥98%
  • MDL No. MFCD00459578
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅ClN₂O
  • Molecular Weight 226.70
  • Synonym(s) Piperazine, 1-benzoyl-, Monohydrochloride
  • SMILES O=C(N1CCNCC1)C2=CC=CC=C2.Cl

Description

1-Benzoylpiperazine hydrochloride is a bench-stable, moisture-tolerant crystalline salt featuring a piperazine core functionalized with a benzoyl group. This compound serves as a key scaffold in medicinal chemistry, integrating a polar amine moiety with an aromatic carbonyl for enhanced solubility and target engagement in CNS-directed drug discovery.

Application

1-Benzoylpiperazine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to piperazine-based pharmacophores. Its well-defined structure offers enhanced solubility and stability under standard synthetic conditions, facilitating direct incorporation into diverse heterocyclic scaffolds. The compound demonstrates robust functional group tolerance, supporting reliable derivatization in amide coupling, alkylation, and reductive amination protocols commonly employed in API development.

Synthesis

  • Route1
    • tert-Butyl 4-benzoylpiperazine-1-carboxylate|CS-M1667
      77278-38-7
    • ~99%
    • In-stock
      1-Benzoylpiperazine hydrochloride|CS-M1666
      56227-55-5

    References

    • Wang, Tao; Wallace, Owen B.; Meanwell, Nicholas A.; Kadow, John F.; Zhang, Zhongxing; Yang, Zhong Patent: US2004/9985 A1, 2004 ; Location in patent: Page/Page column 29 ;
  • Route2

    References

    • Green Chemistry, , vol. 14, # 2 p. 326 - 329
  • Route3

    References

    • Green Chemistry, , vol. 14, # 2 p. 326 - 329

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.34
  • LogP   1.1538
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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