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CS-W001157 4
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6-(4-Formylphenyl)picolinic acid

  • CAS No. 566198-31-0

  • Cat. No. CS-0317623
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-(4-Formylphenyl)picolinic acid|CS-0317623

Structure of 566198-31-0

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General Information

  • CAS No. 566198-31-0
  • Cat. No. CS-0317623
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₉NO₃
  • Molecular Weight 227.22
  • Synonym(s) 6-(4-Formylphenyl)-2-pyridinecarboxylic Acid
  • SMILES C1=CC(=NC(=C1)C(=O)O)C2=CC=C(C=C2)C=O

Description

6-(4-Formylphenyl)picolinic acid features a conjugated aryl-aldehyde linked to a pyridine carboxylic acid scaffold, enabling direct integration into bioconjugation and metal coordination strategies. The para-formyl group provides a reactive handle for hydrazone or amine coupling, while the picolinic acid moiety offers strong chelation potential for transition metals. This bifunctional architecture supports modular synthesis in medicinal chemistry and materials design.

Application

6-(4-Formylphenyl)picolinic acid serves as a versatile bifunctional building block for medicinal chemistry and materials synthesis, combining a pyridine ring with an ortho-carboxylic acid and a para-formylphenyl group. The aldehyde functionality enables efficient imine formation, reductive amination, or Suzuki coupling, while the carboxylic acid supports amide bond construction or metal coordination. Its bench-stable nature and compatibility with standard functional group manipulations make it ideal for modular scaffold assembly in target-oriented synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   67.26
  • LogP   2.2593
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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