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Structure of 56621-48-8
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4-(Piperazin-1-yl)phenol features a phenolic hydroxyl group flanked by a piperazine ring, delivering enhanced solubility and hydrogen-bonding capacity. This combination enables efficient integration into bioactive scaffolds, particularly in kinase inhibitors and antipsychotic leads. The molecule exhibits bench-stable behavior under standard conditions and serves as a key pharmacophore for targeted drug design.
4-(Piperazin-1-yl)phenol serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient construction of diverse heterocyclic scaffolds. Its phenolic hydroxyl group facilitates direct derivatization and metal-catalyzed coupling reactions, while the piperazine moiety offers tunable basicity and hydrogen-bonding capacity. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3259
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302+H312-H314
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Precautionary Statements : P264-P270-P271-P280-P304+P340-P330-P331-P363-P501
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Lot numbers can be found on the outside label of a product: