Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5-Maleimidovaleric acid

  • CAS No. 57078-99-6

  • Cat. No. CS-0115876
  • Purity≥98%
  • MDL No.MFCD04115790

*For research and further manufacturing use only, not for direct human use.

5-Maleimidovaleric acid|CS-0115876

Structure of 57078-99-6

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 57078-99-6
  • Cat. No. CS-0115876
  • Purity ≥98%
  • MDL No. MFCD04115790
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₄
  • Molecular Weight 197.19
  • Synonym(s) None
  • SMILES O=C(O)CCCCN1C(C=CC1=O)=O

Description

5-Maleimidovaleric acid delivers a reactive maleimide group conjugated to a five-carbon aliphatic chain, enabling site-specific bioconjugation via thiol-ene chemistry. The extended spacer enhances solubility and accessibility in protein labeling applications. This derivative combines high reactivity with improved stability under physiological conditions.

Application

5-Maleimidovaleric acid serves as a versatile bifunctional linker for bioconjugation, enabling site-specific attachment of biomolecules via maleimide-thiol chemistry. Its aliphatic chain provides optimal spacing and solubility, while the maleimide group exhibits high reactivity with cysteine residues under physiological conditions. The carboxylic acid terminus facilitates conjugation through amide bond formation or activation with NHS esters, supporting efficient synthesis of antibody-drug conjugates and peptide-protein hybrids.

Synthesis

  • Route1
    • null|null
      108-31-6
    • In-stock
      5-Aminovaleric acid|CS-W016594
      660-88-8
    • ~60%
    • In-stock
      5-Maleimidovaleric acid|CS-0115876
      57078-99-6

    References

    • De Figueiredo, Renata Marcia; Oczipka, Philipp; Froehlich, Roland; Christmann, Mathias Synthesis, 2008 , # 8 p. 1316 - 1318

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   74.68
  • LogP   0.1663
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   5

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 5-Maleimidovaleric acid sigma5-Maleimidovaleric acid manufacturer5-Maleimidovaleric acid price5-Maleimidovaleric acid structure5-Maleimidovaleric acid SDSbuy 5-Maleimidovaleric acid5-Maleimidovaleric acid supplier5-Maleimidovaleric acid uses5-Maleimidovaleric acid molecular weightprice of 5-Maleimidovaleric acid5-Maleimidovaleric acid chemical name formula of 5-Maleimidovaleric acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label