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Structure of 57078-99-6
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5-Maleimidovaleric acid delivers a reactive maleimide group conjugated to a five-carbon aliphatic chain, enabling site-specific bioconjugation via thiol-ene chemistry. The extended spacer enhances solubility and accessibility in protein labeling applications. This derivative combines high reactivity with improved stability under physiological conditions.
5-Maleimidovaleric acid serves as a versatile bifunctional linker for bioconjugation, enabling site-specific attachment of biomolecules via maleimide-thiol chemistry. Its aliphatic chain provides optimal spacing and solubility, while the maleimide group exhibits high reactivity with cysteine residues under physiological conditions. The carboxylic acid terminus facilitates conjugation through amide bond formation or activation with NHS esters, supporting efficient synthesis of antibody-drug conjugates and peptide-protein hybrids.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: