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Structure of 57121-49-0
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4-Ethynyl-1H-pyrazole features a reactive alkyne handle positioned at the 4-position of a stable pyrazole scaffold. This configuration enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and click chemistry applications. The electron-deficient heterocycle enhances regioselectivity in cyclization reactions, while the terminal alkyne supports straightforward derivatization under mild conditions.
4-Ethynyl-1H-pyrazole serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to functionalized pyrazole scaffolds. Its terminal alkyne group facilitates reliable Sonogashira and CuAAC transformations, offering high chemoselectivity and compatibility with diverse functional groups. The compound exhibits excellent bench stability and is readily purified by standard chromatographic methods, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501
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Lot numbers can be found on the outside label of a product: