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CS-W001157 4
Total: USD 88.00

5-Cyclopropyl-1,3,4-thiadiazol-2-amine

  • CAS No. 57235-50-4

  • Cat. No. CS-D0372
  • Molecule weight141.19
  • Purity≥95%
  • MDL No.MFCD00051649

*For research and further manufacturing use only, not for direct human use.

5-Cyclopropyl-1,3,4-thiadiazol-2-amine|CS-D0372

Structure of 57235-50-4

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General Information

  • CAS No. 57235-50-4
  • Cat. No. CS-D0372
  • Purity ≥95%
  • MDL No. MFCD00051649
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇N₃S
  • Molecular Weight 141.19
  • Synonym(s) 2-Amino-5-Cyclopropyl-1,3,4-Thiadiazole
  • SMILES NC1=NN=C(C2CC2)S1

Description

5-Cyclopropyl-1,3,4-thiadiazol-2-amine features a rigid thiadiazole core with a cyclopropyl substituent enhancing lipophilicity and metabolic stability. The primary amine enables direct conjugation or derivatization in medicinal chemistry applications. This scaffold exhibits favorable solubility and bench-stability under standard conditions, making it a robust building block for bioactive molecule design.

Application

5-Cyclopropyl-1,3,4-thiadiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its stable cyclopropyl substituent enhances metabolic resilience, while the thiadiazole amine moiety offers favorable hydrogen-bonding capacity and functional group tolerance. The compound facilitates diverse transformations in standard coupling protocols and functions effectively in parallel synthesis workflows.

Synthesis

  • Route1
    • null|null
      4023-34-1
    • In-stock
      Thiosemicarbazide|CS-0008325
      79-19-6
    • ~64%
    • In-stock
      5-Cyclopropyl-1,3,4-thiadiazol-2-amine|CS-D0372
      57235-50-4

    References

    • Noolvi, Malleshappa N.; Patel, Harun M.; Singh, Navjot; Gadad, Andanappa K.; Cameotra, Swaranjit Singh; Badiger, Arvind European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4411 - 4418
  • Route2

    References

    • Heterocyclic Communications, , vol. 13, # 6 p. 387 - 392

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   0.9977
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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