5,7-Dichloroimidazo[1,2-a]pyrimidine

Name: 5,7-Dichloroimidazo[1,2-a]pyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 57473-32-2
Cat. No. CS-W022278
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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*For research and further manufacturing use only, not for direct human use.

5,7-Dichloroimidazo[1,2-a]pyrimidine|CS-W022278

Structure of 57473-32-2

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Description

5,7-Dichloroimidazo[1,2-a]pyrimidine serves as a potent electrophilic scaffold in medicinal chemistry, featuring two chlorine substituents that enhance reactivity at the imidazopyrimidine core. This electron-deficient heterocycle integrates readily into kinase inhibitors and nucleoside analogs, offering high functional group tolerance and stability under standard bench conditions.

Application

5,7-Dichloroimidazo[1,2-a]pyrimidine serves as a versatile building block for heterocyclic synthesis, enabling efficient access to imidazo[1,2-a]pyrimidine scaffolds prevalent in medicinal chemistry. The dichloro substitution pattern provides orthogonal reactivity for nucleophilic displacement, facilitating the installation of diverse N- and C-substituents under mild conditions. Its bench-stable solid form and compatibility with standard coupling protocols make it ideal for high-throughput library generation and scale-up applications.

General Information

CAS No. 57473-32-2
Cat. No. CS-W022278
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃Cl₂N₃
Molecular Weight 188.01
Synonym(s) 5,7-Dichloroimidazo[1,2-α]pyrimidine
SMILES ClC1=NC2=NC=CN2C(Cl)=C1

Computational Chemistry Data

TPSA 30.19
LogP 2.0361
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Key Words

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5,7-Dichloroimidazo[1,2-a]pyrimidine

CAS No. 57473-32-2

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