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Structure of 5757-66-4
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4-Bromo-2,6-dimethylbenzonitrile features a sterically hindered aromatic core with complementary electron-withdrawing nitrile and bromine substituents. This configuration enables selective cross-coupling reactions under mild conditions, while the methyl groups enhance solubility and stability in organic media.
4-Bromo-2,6-dimethylbenzonitrile serves as a versatile building block in medicinal chemistry and materials science, enabling palladium-catalyzed cross-coupling reactions due to its stable nitrile group and ortho-methyl substitution pattern. The bromine functionality facilitates Suzuki, Stille, and Negishi couplings, while the electron-withdrawing nitrile enhances reactivity in nucleophilic aromatic substitution. Its bench-stable crystalline form simplifies handling and purification, making it ideal for multi-step synthesis of functionalized heterocycles and advanced API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: