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Structure of 588702-62-9
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4-(Trifluoromethyl)picolinic acid features a trifluoromethyl group at the para position of the picolinic ring, enhancing electron-withdrawal and metabolic stability. This structural motif enables efficient coupling in amide bond formation, particularly in peptide synthesis and medicinal chemistry applications. The compound exhibits robust bench-stability and solubility under standard conditions.
4-(Trifluoromethyl)picolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the pyridine carboxylic acid functionality facilitates straightforward derivatization via amide formation, esterification, or metal-catalyzed coupling reactions. The compound exhibits excellent bench stability and compatibility with standard purification protocols, making it well-suited for scalable synthetic applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302+H312+H332
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
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Lot numbers can be found on the outside label of a product: