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Structure of 936841-69-9
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4-(Trifluoromethyl)picolinonitrile features a trifluoromethyl group at the 4-position of picolinonitrile, enhancing electron-withdrawal and metabolic stability. This electron-deficient heterocycle integrates readily into synthetic routes for pharmaceutical intermediates, offering robust reactivity under standard conditions.
4-(Trifluoromethyl)picolinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through its dual functionality: the nitrile group facilitates cyclizations and amidation reactions, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity. Its bench-stable nature and compatibility with standard coupling conditions make it suitable for scalable synthesis of pharmaceutical intermediates and functionalized pyridine scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: