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CS-W001157 4
Total: USD 88.00

Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate Avanafil Impurity

  • CAS No. 5909-24-0

  • Cat. No. CS-0228709
  • Purity≥97%
  • MDL No.MFCD00006085

*For research and further manufacturing use only, not for direct human use.

Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate Avanafil  Impurity|CS-0228709

Structure of 5909-24-0

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General Information

  • CAS No. 5909-24-0
  • Cat. No. CS-0228709
  • Purity ≥97%
  • MDL No. MFCD00006085
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClN₂O₂S
  • Molecular Weight 232.69
  • Synonym(s) None
  • SMILES O=C(OCC)C1=CN=C(SC)N=C1Cl

Synthesis

  • Route1
    • Ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate  Avanafil Impurity|CS-0166957
      53554-29-3
    • ~77%
    • Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate Avanafil  Impurity|CS-0228709
      5909-24-0

    References

    • DECIPHERA PHARMACEUTICALS, LLC Patent: WO2006/71940 A2, 2006 ; Location in patent: Page/Page column 354 ; WO 2006/071940 A2
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 15 p. 1645 - 1648

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   52.08
  • LogP   2.0286
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   3

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