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Structure of 59514-89-5
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2,4-Dichloro-1,8-naphthyridine is a bench-stable, electron-deficient heterocycle featuring two chlorine substituents at positions 2 and 4. This configuration enhances its utility in transition metal-catalyzed cross-coupling reactions, where the chlorides serve as effective coupling partners. The fused bicyclic scaffold provides rigidity and improved solubility in common organic solvents, facilitating integration into complex molecular architectures.
2,4-Dichloro-1,8-naphthyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its electron-deficient heterocyclic core exhibits excellent bench stability and compatibility with diverse nucleophiles, facilitating the construction of biologically active scaffolds. The dichloro substitution pattern provides orthogonal reactivity for sequential derivatization, making it particularly valuable in API development workflows requiring precise structural control.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: