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CS-W001157 4
Total: USD 88.00

Triethylphosphineoxide

  • CAS No. 597-50-2

  • Cat. No. CS-0639605
  • Molecule weight134.16
  • Purity≥98%
  • MDL No.MFCD00013914

*For research and further manufacturing use only, not for direct human use.

Triethylphosphineoxide|CS-0639605

Structure of 597-50-2

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General Information

  • CAS No. 597-50-2
  • Cat. No. CS-0639605
  • Purity ≥98%
  • MDL No. MFCD00013914
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₅OP
  • Molecular Weight 134.16
  • Synonym(s) None
  • SMILES CCP(=O)(CC)CC

Description

Mizoribine is an imidazole nucleoside immunosuppressant agent that was first isolated from the mold Eupenicillium brefeldimium with antibiotic and cytotoxic effects. Mizoribine has been used in kidney transplantation, which is the optimal form of therapy for children and adolescents with end-stage kidney disease. The compound has also been used to treat steroid-resistant nephrotic syndrome, IgA nephropathy, lupus, as well as for adults with rheumatoid arthritis, lupus nephritis and other rheumatic diseases. Mizoribine's mode of action is via selective inhibition of inosine monophosphate synthetase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis without incorporation into nucleotides.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.4092
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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