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CS-W001157 4
Total: USD 88.00

N-Acetyl-D-proline

  • CAS No. 59785-68-1

  • Cat. No. CS-W017974
  • Purity≥97%
  • MDL No.MFCD00080841

*For research and further manufacturing use only, not for direct human use.

N-Acetyl-D-proline|CS-W017974

Structure of 59785-68-1

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General Information

  • CAS No. 59785-68-1
  • Cat. No. CS-W017974
  • Purity ≥97%
  • MDL No. MFCD00080841
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁NO₃
  • Molecular Weight None
  • Synonym(s) None
  • SMILES OC([C@@H]1N(CCC1)C(C)=O)=O

Description

N-Acetyl-D-proline features a stable acetylated D-proline scaffold with enhanced solubility and resistance to racemization. This derivative integrates seamlessly into peptide synthesis workflows, serving as a valuable chiral building block for constrained peptidomimetics and bioactive oligomers under standard conditions.

Application

N-Acetyl-D-proline serves as a valuable chiral building block in peptide synthesis and medicinal chemistry, offering enhanced stability and solubility compared to unprotected proline derivatives. Its acetylated nitrogen facilitates efficient incorporation into peptide sequences, while the D-configured pyrrolidine ring provides stereochemical control in constrained peptidomimetics. The compound exhibits excellent bench stability, mild reactivity under standard coupling conditions, and compatibility with diverse functional groups, enabling straightforward purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   57.61
  • LogP   0.0819
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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