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CS-W001157 4
Total: USD 88.00

1-Bromo-2-fluoro-3-methyl-benzene

  • CAS No. 59907-12-9

  • Cat. No. CS-W003215
  • Purity≥98%
  • MDL No.MFCD04972694
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

1-Bromo-2-fluoro-3-methyl-benzene|CS-W003215

Structure of 59907-12-9

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Description

1-Bromo-2-fluoro-3-methyl-benzene features a strategically positioned bromine, fluorine, and methyl group on a benzene ring, enabling selective cross-coupling reactions. The ortho-fluoro substituent enhances reactivity in palladium-catalyzed transformations, while the methyl group provides steric and electronic modulation. This compound serves as a key intermediate in the synthesis of functionalized aromatic systems for pharmaceutical and agrochemical applications.

Application

1-Bromo-2-fluoro-3-methylbenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura and Negishi couplings. The ortho-fluoro and bromo substituents offer complementary reactivity for sequential functionalization, while the methyl group provides a stable, electron-donating handle. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex aromatic scaffolds.

General Information

  • CAS No. 59907-12-9
  • Cat. No. CS-W003215
  • Purity ≥98%
  • MDL No. MFCD04972694
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆BrF
  • Molecular Weight 189.03
  • Synonym(s) 3-Bromo-2-fluorotoluene
  • SMILES Fc1c(C)cccc1Br

Computational Chemistry Data

  • TPSA   0
  • LogP   2.89662
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H302-H315-H319-H335
Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501

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