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Structure of 452-62-0
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2-Bromo-1-fluoro-4-methylbenzene features a strategically positioned bromo and fluoro substituent flanking a methyl group on the benzene ring. This ortho-difunctionalized scaffold enables direct coupling reactions in cross-coupling protocols, offering enhanced regiocontrol. The molecule exhibits bench-stable handling characteristics and compatibility with palladium-catalyzed transformations.
2-Bromo-1-fluoro-4-methylbenzene serves as a versatile building block in cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its ortho-bromine facilitates palladium-catalyzed coupling with boronic acids and amines, while the fluoro and methyl groups provide orthogonal reactivity and steric control. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it ideal for iterative synthesis in medicinal chemistry and process development workflows.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: