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CS-W001157 4
Total: USD 88.00

H-Ser-OBzl.HCl

  • CAS No. 60022-62-0

  • Cat. No. CS-W010363
  • Purity≥96%
  • MDL No.MFCD00038955

*For research and further manufacturing use only, not for direct human use.

H-Ser-OBzl.HCl|CS-W010363

Structure of 60022-62-0

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General Information

  • CAS No. 60022-62-0
  • Cat. No. CS-W010363
  • Purity ≥96%
  • MDL No. MFCD00038955
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄ClNO₃
  • Molecular Weight 231.68
  • Synonym(s) L-Serine benzyl ester hydrochloride
  • SMILES N[C@@](C(OCC1=CC=CC=C1)=O)([H])CO.Cl

Description

H-Ser-OBzl.HCl features a protected serine residue with a benzyl ester group, offering enhanced stability and ease of handling in peptide synthesis. The protonated form ensures solubility in aqueous buffers, enabling efficient coupling under standard conditions. This derivative integrates seamlessly into N-terminal extensions during solid-phase workflows.

Application

H-Ser-OBzl·HCl serves as a stable, bench-ready building block for peptide synthesis, enabling efficient incorporation of serine residues with orthogonal protection. The benzyl ester group provides excellent stability and compatibility with standard deprotection protocols, while the hydrochloride salt enhances solubility and handling. This derivative facilitates reliable coupling reactions and purification in both solution-phase and solid-phase workflows, making it a practical choice for constructing complex peptide sequences and bioactive scaffolds.

Synthesis

  • Route1

    References

    • Thorn, Karina; Nielsen, Carsten Uhd; Jakobsen, Palle; Steffansen, Bente; Zercher, Charles K.; Begtrup, Mikael Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4597 - 4601

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   0.4712
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   4

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