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CS-W001157 4
Total: USD 88.00

2,4,6-Trichloro-3-nitropyridine

  • CAS No. 60186-13-2

  • Cat. No. CS-W021497
  • Molecule weight227.43
  • Purity≥98%
  • MDL No.MFCD09264535

*For research and further manufacturing use only, not for direct human use.

2,4,6-Trichloro-3-nitropyridine|CS-W021497

Structure of 60186-13-2

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General Information

  • CAS No. 60186-13-2
  • Cat. No. CS-W021497
  • Purity ≥98%
  • MDL No. MFCD09264535
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅HCl₃N₂O₂
  • Molecular Weight 227.43
  • Synonym(s) Pyridine,4-chloro-2,6-dimethyl-3-nitro
  • SMILES O=[N+](C1=C(Cl)C=C(Cl)N=C1Cl)[O-]

Description

2,4,6-Trichloro-3-nitropyridine features a highly electron-deficient pyridine core stabilized by three chlorine substituents and a nitro group at the 3-position. This configuration enables selective coupling reactions in synthetic organic chemistry, particularly in the construction of heterocyclic scaffolds under mild conditions. The compound exhibits excellent bench stability and compatibility with diverse reaction environments.

Application

2,4,6-Trichloro-3-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling selective functionalization at the 3-position via nucleophilic substitution. Its electron-deficient pyridine core facilitates robust reactivity with amines, thiols, and other nucleophiles under mild conditions. The molecule exhibits excellent bench stability and ease of purification, making it well-suited for scalable synthesis of advanced intermediates in medicinal chemistry and agrochemical development.

Synthesis

  • Route1

    References

    • Xuanzhu Pharmaco., Ltd. Patent: EP2524917 A1, 2012 ; Location in patent: Page/Page column 58; 60 ;
  • Route2

    References

    • Xuanzhu Pharma Co., Ltd. Patent: US2012/289497 A1, 2012 ; Title/Abstract Full Text Show Details Xuanzhu Pharmaco., Ltd. Patent: EP2524917 A1, 2012 ;
  • Route3
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      2587-00-0
    • ~%
    • In-stock
      2,4,6-Trichloro-3-nitropyridine|CS-W021497
      60186-13-2

    References

    • Xuanzhu Pharma Co., Ltd. Patent: US2012/289497 A1, 2012 ; Title/Abstract Full Text Show Details Xuanzhu Pharmaco., Ltd. Patent: EP2524917 A1, 2012 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   2.95
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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