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CS-W001157 4
Total: USD 88.00

Methyl 2-methoxybenzoate

  • CAS No. 606-45-1

  • Cat. No. CS-0014015
  • Molecule weight166.18
  • Purity≥98%
  • MDL No.MFCD00008423

*For research and further manufacturing use only, not for direct human use.

Methyl 2-methoxybenzoate|CS-0014015

Structure of 606-45-1

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General Information

  • CAS No. 606-45-1
  • Cat. No. CS-0014015
  • Purity ≥98%
  • MDL No. MFCD00008423
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₃
  • Molecular Weight 166.18
  • Synonym(s) None
  • SMILES COC1=CC=CC=C1C(OC)=O

Description

FeCl2 catalyzed cross-coupling reaction between methyl 2-methoxybenzoate and diphenylmethane under various reaction conditions has been investigated.Methyl 2-methoxybenzoate has been used in the synthesis of (+/)-vibralactone.

Application

Methyl 2-methoxybenzoate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted benzoic acid derivatives and heterocyclic scaffolds. Its ortho-methoxy and ester functionalities exhibit excellent compatibility with standard coupling reactions, hydrogenation, and electrophilic transformations. The compound demonstrates robust bench stability, facilitates straightforward purification, and functions reliably in multi-step syntheses of pharmaceutical intermediates and functional materials.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      2-Methoxybenzoic acid|CS-W019888
      579-75-9
    • ~10%
    • In-stock
      Methyl 2-methoxybenzoate|CS-0014015
      606-45-1

    References

    • Bodnar, Brian S.; Vogt, Paul F. Journal of Organic Chemistry, 2009 , vol. 74, # 6 p. 2598 - 2600
  • Route2
    • null|null
      77-78-1
    • Salicylic acid, ≥99%|CS-1268363
      69-72-7
    • ~82%
    • In-stock
      Methyl 2-methoxybenzoate|CS-0014015
      606-45-1

    References

    • Kundu, Tapas Kumar; Balasubramanyam, Karanam; Swaminathan, Vankatesh Patent: US2006/167107 A1, 2006 ; Location in patent: Page/Page column 4 ; US 20060167107 A1
  • Route3
    • null|null
      67-56-1
    • 2-Methoxybenzaldehyde, ≥97%|CS-1269021
      135-02-4
    • ~96%
    • In-stock
      Methyl 2-methoxybenzoate|CS-0014015
      606-45-1

    References

    • Gopinath, Rangam; Barkakaty, Balaka; Talukdar, Bandana; Patel, Bhisma K. Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2944 - 2947

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   1.4818
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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