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Structure of 607-68-1
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2,4-Dichloroquinazoline is a bench-stable, electron-deficient heterocycle featuring two chlorine substituents at the 2- and 4-positions of the quinazoline core. This configuration enhances reactivity in nucleophilic substitution processes, enabling efficient coupling with amines, thiols, and other soft nucleophiles under mild conditions. The molecule integrates readily into bioactive scaffolds due to its planar structure and moderate lipophilicity, making it valuable for medicinal chemistry and chemical biology applications.
2,4-Dichloroquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinazoline-based scaffolds. The dichloro substitution pattern facilitates regioselective palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitution, offering reliable access to functionalized derivatives. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: