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Structure of 959237-34-4
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2,4-Dichloro-7-iodoquinazoline features a halogenated quinazoline core with complementary electron-deficient and reactive sites. The para-iodo group enables facile cross-coupling, while the 2,4-dichloro substitution pattern provides regioselective functionalization potential. This scaffold delivers high reactivity in palladium-catalyzed transformations and serves as a key intermediate for bioactive molecule synthesis.
2,4-Dichloro-7-iodoquinazoline serves as a versatile building block for the synthesis of quinazoline-based pharmaceutical intermediates and kinase inhibitors. The strategic placement of chloro and iodo groups enables sequential cross-coupling reactions under palladium catalysis, facilitating rapid diversification at the 2-, 4-, and 7-positions. Its bench-stable nature and compatibility with standard coupling conditions make it ideal for iterative medicinal chemistry campaigns and API scaffold elaboration.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: