(6-Amino-2-pyridinyl)(1-methyl-4-piperidinyl)methanone

Name: (6-Amino-2-pyridinyl)(1-methyl-4-piperidinyl)methanone
Brand: ChemScene
Availability: InStock
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CAS No. 613678-03-8
Cat. No. CS-0021415
Molecule weight219.28
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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(6-Amino-2-pyridinyl)(1-methyl-4-piperidinyl)methanone|CS-0021415

Structure of 613678-03-8

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General Information

CAS No. 613678-03-8
Cat. No. CS-0021415
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₇N₃O
Molecular Weight 219.28
Synonym(s) (6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone
SMILES O=C(C1=NC(N)=CC=C1)C2CCN(C)CC2

Description

This pyridine-piperidine hybrid delivers a strategically positioned amine and carbonyl for targeted conjugation. The 6-amino-2-pyridinyl moiety enables metal coordination and hydrogen bonding, while the 1-methyl-4-piperidinyl group provides solubility and steric resilience. Bench-stable under standard conditions, it integrates readily into medicinal chemistry scaffolds requiring polar, nitrogen-rich motifs.

Application

(6-Amino-2-pyridinyl)(1-methyl-4-piperidinyl)methanone serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through amide coupling and cyclization reactions. Its pyridine-amino motif offers enhanced solubility and hydrogen-bonding capacity, while the piperidinyl carbonyl functions as a stable, synthetically accessible handle for further derivatization. The compound exhibits good bench stability and facilitates purification via standard chromatographic methods, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

Route1
- 613678-08-3
- ~%
- In-stock
  
  613678-03-8
References
- ELI LILLY AND COMPANY Patent: WO2003/84949 A1, 2003 ; Location in patent: Page/Page column 48 ; WO 03/084949 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

TPSA 59.22
LogP 1.1883
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Ketone

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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(6-Amino-2-pyridinyl)(1-methyl-4-piperidinyl)methanone

CAS No. 613678-03-8

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