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3-Chloro-4-methylphenol

  • CAS No. 615-62-3

  • Cat. No. CS-W002279
  • Purity≥98%
  • MDL No.MFCD00060319

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-methylphenol|CS-W002279

Structure of 615-62-3

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General Information

  • CAS No. 615-62-3
  • Cat. No. CS-W002279
  • Purity ≥98%
  • MDL No. MFCD00060319
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClO
  • Molecular Weight 142.58
  • Synonym(s) Phenol, 3-chloro-4-methyl-
  • SMILES Oc1ccc(c(c1)Cl)C

Description

3-Chloro-4-methylphenol features a chlorinated aromatic ring with adjacent methyl and hydroxyl groups, delivering enhanced reactivity for electrophilic substitution. This electron-rich scaffold enables direct functionalization in synthetic pathways, particularly useful in agrochemical and pharmaceutical intermediates. The molecule exhibits bench-stable handling under standard conditions.

Application

3-Chloro-4-methylphenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted aromatic scaffolds. Its ortho-chloro and para-methyl groups provide distinct reactivity profiles for palladium-catalyzed coupling reactions and electrophilic functionalization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for scale-up and multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • DE156333 ;
  • Route2

    References

    • Tetrahedron, , vol. 39, # 1 p. 193 - 198
  • Route3
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    • ~%
    • In-stock
      3-Chloro-4-methylphenol|CS-W002279
      615-62-3

    References

    • Canadian Journal of Chemistry, , vol. 65, p. 1233 - 1240

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.35402
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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