H-DL-Nle-OH

Name: H-DL-Nle-OH
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CAS No. 616-06-8
Cat. No. CS-W013425
Molecule weightNone
Purity≥98%
MDL No.MFCD00064422

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Structure of 616-06-8

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General Information

CAS No. 616-06-8
Cat. No. CS-W013425
Purity ≥98%
MDL No. MFCD00064422
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₃NO₂
Molecular Weight None
Synonym(s) 2-Aminohexanoic acid;DL-2-Aminohexanoic acid;DL-Norleucine
SMILES CCCCC(N)C(O)=O

Description

Intercalating into metabolic flux pathways, DL-Norleucine (CAS 616-06-8) disrupts amino acid incorporation during protein synthesis and alters nitrogen balance in mammalian cell cultures.

Application

DL-Norleucine (CAS 616-06-8) drives protein synthesis studies by enabling the incorporation of non-standard amino acids into peptides, revealing how structural changes impact functional dynamics. It alters metabolic flux in live systems. Researchers leverage this to map disrupted amino acid pathways linked to inherited disorders. This setup streamlines drug design targeting specific metabolic nodes. It also enhances protein supplement efficacy for muscle recovery.

Synthesis

Route1
- 616-05-7
- ~%
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  616-06-8
References
- Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 86, p. 455 Journal of the American Chemical Society, , vol. 42, p. 316
Route2
- In-stock
  
  2492-75-3
- ~%
- In-stock
  
  616-06-8
References
- Organic and Biomolecular Chemistry, , vol. 2, # 18 p. 2684 - 2691
Route3
- 126181-38-2
- ~92%
- In-stock
  
  616-06-8
References
- Bazureau, J.P.; Person, D.; Corre, M. Le Tetrahedron Letters, 1989 , vol. 30, # 23 p. 3065 - 3068

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 63.32
LogP 0.5885
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 4

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Leucine and derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Peptide Chemistry Unnatural Amino Acid Derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids non-Proteinogenic Amino Acids

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H-DL-Nle-OH

CAS No. 616-06-8

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