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CS-W001157 4
Total: USD 88.00

2,3,4,9-Tetrahydro-1H-carbazol-3-amine

  • CAS No. 61894-99-3

  • Cat. No. CS-0042638
  • Purity≥98%
  • MDL No.MFCD02181027

*For research and further manufacturing use only, not for direct human use.

2,3,4,9-Tetrahydro-1H-carbazol-3-amine|CS-0042638

Structure of 61894-99-3

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General Information

  • CAS No. 61894-99-3
  • Cat. No. CS-0042638
  • Purity ≥98%
  • MDL No. MFCD02181027
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₄N₂
  • Molecular Weight 186.25
  • Synonym(s) Intermediate of ramatroban
  • SMILES NC1CCC(NC2=C3C=CC=C2)=C3C1

Description

2,3,4,9-Tetrahydro-1H-carbazol-3-amine is a bench-stable heterocyclic amine featuring a fused tricyclic core with a primary amine at the 3-position. This scaffold integrates readily into pharmaceutical intermediates and functional materials, offering enhanced solubility and stability compared to fully aromatic analogs.

Application

2,3,4,9-Tetrahydro-1H-carbazol-3-amine serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds. Its amine functionality facilitates straightforward derivatization via alkylation, acylation, and coupling reactions. The tetrahydrocarbazole core exhibits good bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • In-stock
      1,4-Dioxaspiro[4.5]decan-8-amine|CS-0040044
      97096-16-7
    • null|null
      100-63-0
    • ~50%
    • In-stock
      2,3,4,9-Tetrahydro-1H-carbazol-3-amine|CS-0042638
      61894-99-3

    References

    • Nirogi, Ramakrishna V. S.; Konda, Jagadishu Babu; Kambhampati, Ramasastry; Shinde, Anil; Bandyala, Thrinath Reddy; Gudla, Parandhama; Kandukuri, Kiran Kumar; Jayarajan, Pradeep; Kandikere, Vishwottam; Dubey, P. K. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6980 - 6985,6
  • Route2
    • null|null
      1234493-21-0
    • ~%
    • In-stock
      2,3,4,9-Tetrahydro-1H-carbazol-3-amine|CS-0042638
      61894-99-3

    References

    • WO2010/78250 A1, ; Page/Page column 13 ;
  • Route3

    References

    • Journal of Physical Chemistry, , vol. 99, p. 5713 - 5723

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.81
  • LogP   1.9839
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   0

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