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Structure of 620-16-6
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1-Chloro-3-ethylbenzene is a para-substituted aromatic halide featuring an ethyl group flanking the chlorine atom. This configuration enhances its stability and facilitates selective functionalization in cross-coupling reactions. The molecule exhibits favorable solubility in organic solvents and maintains integrity under standard bench conditions, enabling reliable use in synthetic pathways requiring controlled electrophilic reactivity.
1-Chloro-3-ethylbenzene serves as a versatile aryl halide building block in cross-coupling reactions, enabling efficient C–C bond formation under palladium catalysis. Its ortho-substituted ethyl group provides steric and electronic modulation, enhancing regioselectivity in Suzuki-Miyaura and Negishi couplings. The compound exhibits excellent bench stability, minimal side reactivity, and facilitates straightforward purification via distillation or column chromatography, making it well-suited for iterative synthesis of functionalized biaryls and complex aromatic scaffolds.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H302-H315-H319-H335
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Precautionary Statements : P210-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P403-P405-P501
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Lot numbers can be found on the outside label of a product: