5-Aminopyridine-3-sulfonamide

Name: 5-Aminopyridine-3-sulfonamide
Brand: ChemScene
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CAS No. 62009-21-6
Cat. No. CS-0139493
Molecule weight173.19
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Aminopyridine-3-sulfonamide|CS-0139493

Structure of 62009-21-6

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General Information

CAS No. 62009-21-6
Cat. No. CS-0139493
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₇N₃O₂S
Molecular Weight 173.19
Synonym(s) 3-Pyridinesulfonamide,5-amino-(9CI)
SMILES O=S(C1=CC(N)=CN=C1)(N)=O

Description

5-Aminopyridine-3-sulfonamide features a dual functional group architecture combining a nucleophilic amine and a sulfonamide moiety, enabling versatile conjugation in medicinal chemistry. The electron-rich pyridine ring enhances reactivity in transition-metal-catalyzed couplings, while the sulfonamide imparts metabolic stability and hydrogen-bonding capacity. This scaffold serves as a key building block for kinase inhibitors and bioactive heterocycles.

Application

5-Aminopyridine-3-sulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through its dual amine and sulfonamide functionalities. The molecule exhibits good bench stability and facilitates diverse transformations, including coupling reactions and derivatization, owing to its well-defined reactivity and compatibility with standard synthetic protocols.

Synthesis

Route1
- 62009-33-0
- ~62%
- In-stock
  
  62009-21-6
References
- Morisawa, Yasuhiro; Kataoka, Mitsuru; Nagahori, Hitoshi; Sakamoto, Toshiaki; Kitano, Noritoshi; et al. Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1376 - 1380
Route2
- 62009-33-0
- In-stock
  
  7758-99-8
- ~%
- In-stock
  
  62009-21-6
References
- Sankyo Company Limited Patent: US4094982 A1, 1978 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

TPSA 99.07
LogP -0.6888
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Sulfonamide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Aminopyridine-3-sulfonamide

CAS No. 62009-21-6

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