2,4-Dichloro-7-methoxyquinazoline

Name: 2,4-Dichloro-7-methoxyquinazoline
Brand: ChemScene
Availability: InStock
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CAS No. 62484-31-5
Cat. No. CS-W019059
Purity≥97%
MDL No.MFCD09954881

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4-Dichloro-7-methoxyquinazoline|CS-W019059

Structure of 62484-31-5

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Description

2,4-Dichloro-7-methoxyquinazoline features a sterically accessible quinazoline core with electron-withdrawing chloro groups at positions 2 and 4, paired with a methoxy substituent at C7. This combination enhances electrophilicity for nucleophilic substitution and improves solubility in polar organic media. The compound serves as a key scaffold in kinase inhibitor development and is compatible with standard coupling protocols under mild conditions.

Application

2,4-Dichloro-7-methoxyquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinazoline-based scaffolds. The dichloro substitution pattern facilitates sequential nucleophilic aromatic substitution, allowing selective introduction of diverse amine and heterocyclic moieties. Its methoxy group enhances solubility and modulates electronic properties, while the compound exhibits excellent bench stability and ease of purification—key advantages for high-throughput synthesis and process development.

General Information

CAS No. 62484-31-5
Cat. No. CS-W019059
Purity ≥97%
MDL No. MFCD09954881
Storage -20°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₆Cl₂N₂O
Molecular Weight 229.06
Synonym(s) T66 BN DNJ CG EG IO1
SMILES ClC2=NC1=CC(=CC=C1C(=N2)Cl)OC

Computational Chemistry Data

TPSA 35.01
LogP 2.9452
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Quinazoline compounds

Key Words

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2,4-Dichloro-7-methoxyquinazoline

CAS No. 62484-31-5

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