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8-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine

  • CAS No. 625394-65-2

  • Cat. No. CS-0097833
  • Molecule weight214.06
  • Purity≥97%
  • MDL No.MFCD08544331

*For research and further manufacturing use only, not for direct human use.

8-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine|CS-0097833

Structure of 625394-65-2

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General Information

  • CAS No. 625394-65-2
  • Cat. No. CS-0097833
  • Purity ≥97%
  • MDL No. MFCD08544331
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrNO
  • Molecular Weight 214.06
  • Synonym(s) 8-Bromo-3,4-dihydro-2H-1,4-benzoxazine
  • SMILES BrC1=C(OCCN2)C2=CC=C1

Description

8-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine is a heterocyclic scaffold featuring a brominated benzene ring fused to a saturated oxazine core. This configuration imparts enhanced stability and tunable reactivity, enabling its use in transition-metal-catalyzed coupling reactions. The bromine substituent serves as a strategic handle for further functionalization, facilitating the construction of complex molecular architectures in medicinal chemistry and materials science.

Application

8-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its bromine substituent enables facile palladium-catalyzed cross-coupling reactions, while the dihydrooxazine core offers stability and compatibility with standard synthetic transformations. The scaffold functions effectively in the construction of bioactive molecules and demonstrates favorable handling properties for bench-scale applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.2534
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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