2-Chloro-5-fluoropyrimidine

Name: 2-Chloro-5-fluoropyrimidine
Brand: ChemScene
Availability: InStock
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CAS No. 62802-42-0
Cat. No. CS-D1783
Purity≥97%
MDL No.MFCD03788197

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 62802-42-0

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General Information

CAS No. 62802-42-0
Cat. No. CS-D1783
Purity ≥97%
MDL No. MFCD03788197
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₂ClFN₂
Molecular Weight None
Synonym(s) 5-Fluoro-2-chloropyrimidine; Pyrimidine, 2-chloro-5-fluoro-
SMILES FC1=CN=C(Cl)N=C1

Description

2-Chloro-5-fluoropyrimidine is a heterocyclic building block featuring complementary halogen substituents at adjacent positions. This electron-deficient pyrimidine integrates readily into cross-coupling reactions and serves as a key scaffold in medicinal chemistry. The molecule exhibits enhanced stability under standard conditions and facilitates efficient derivatization through palladium-catalyzed transformations.

Application

2-Chloro-5-fluoropyrimidine serves as a versatile building block in medicinal chemistry, enabling nucleophilic substitution reactions at the C2 position while retaining fluorine reactivity at C5. Its dual electrophilic sites facilitate the construction of complex heterocyclic scaffolds and functionalized pyrimidine derivatives used in agrochemicals and pharmaceutical development. The compound exhibits good bench stability, compatibility with diverse reaction conditions, and ease of purification, making it well-suited for scalable synthesis workflows.

Synthesis

Route1
- In-stock
  
  2927-71-1
- ~74%
- In-stock
  
  62802-42-0
References
- De Savi, Chris; Pape, Andrew; Cumming, John G.; Ting, Attilla; Smith, Peter D.; Burrows, Jeremy N.; Mills, Mark; Davies, Chris; Lamont, Scott; Milne, David; Cook, Calum; Moore, Peter; Sawyer, Yvonne; Gerhardt, Stefan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1376 - 1381
Route2
- In-stock
  
  6693-08-9
- ~77%
- In-stock
  
  62802-42-0
References
- Baasner, B.; Klauke, E. Journal of Fluorine Chemistry, 1989 , vol. 45, p. 417 - 430

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅲ
Hazard Statements : H227-H302-H314
Precautionary Statements : P210-P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P370+P378-P403-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 25.78
LogP 1.2691
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-5-fluoropyrimidine

CAS No. 62802-42-0

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