3-Bromo-8-fluoroimidazo[1,2-a]pyridine

Name: 3-Bromo-8-fluoroimidazo[1,2-a]pyridine
Brand: ChemScene
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CAS No. 628691-73-6
Cat. No. CS-0038788
Purity≥97%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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3-Bromo-8-fluoroimidazo[1,2-a]pyridine|CS-0038788

Structure of 628691-73-6

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Description

3-Bromo-8-fluoroimidazo[1,2-a]pyridine is a heterocyclic building block featuring complementary halogen handles for cross-coupling. The bromine and fluorine substituents enable sequential functionalization via palladium-catalyzed reactions, while the imidazo[1,2-a]pyridine core provides rigidity and electronic tunability. This compound supports efficient access to complex nitrogen-containing scaffolds in medicinal chemistry and materials science.

Application

3-Bromo-8-fluoroimidazo[1,2-a]pyridine serves as a versatile building block for constructing bioactive heterocycles, enabling palladium-catalyzed cross-coupling reactions with broad functional group tolerance. The ortho-halogen substitution pattern facilitates selective derivatization, while the imidazo[1,2-a]pyridine core provides structural rigidity and enhanced metabolic stability. This compound exhibits excellent bench stability and simplifies purification in multi-step synthesis workflows.

General Information

CAS No. 628691-73-6
Cat. No. CS-0038788
Purity ≥97%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄BrFN₂
Molecular Weight 215.02
Synonym(s) 3-bromo-8-fluoroH-imidazo[1,2-a]pyridine
SMILES C1=CN2C(=CN=C2C(=C1)F)Br

Computational Chemistry Data

TPSA 17.3
LogP 2.2359
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Bromo-8-fluoroimidazo[1,2-a]pyridine

CAS No. 628691-73-6

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