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CS-W001157 4
Total: USD 88.00

2,4-Dichloro-3-fluoropyridine

  • CAS No. 628691-85-0

  • Cat. No. CS-W006715
  • Purity≥95%
  • MDL No.MFCD12196994
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,4-Dichloro-3-fluoropyridine|CS-W006715

Structure of 628691-85-0

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Description

2,4-Dichloro-3-fluoropyridine features a strategically positioned fluorine and two chlorine atoms on the pyridine ring, creating a highly electron-deficient heterocyclic scaffold. This combination enables selective coupling reactions in pharmaceutical synthesis, particularly in cross-coupling and nucleophilic aromatic substitution processes. The molecule exhibits enhanced reactivity and stability under standard conditions, making it a valuable building block for complex heterocyclic systems.

Application

2,4-Dichloro-3-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling selective nucleophilic substitution reactions due to its orthogonal halogen reactivity. The fluorine atom at C3 facilitates directed metalation, while the dichloro substitution pattern supports sequential coupling strategies. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling make it ideal for constructing complex heterocyclic scaffolds in API development.

General Information

  • CAS No. 628691-85-0
  • Cat. No. CS-W006715
  • Purity ≥95%
  • MDL No. MFCD12196994
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Cl₂FN
  • Molecular Weight 165.98
  • Synonym(s) None
  • SMILES FC1=C(Cl)C=CN=C1Cl

Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.5275
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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