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Structure of 628691-85-0
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2,4-Dichloro-3-fluoropyridine features a strategically positioned fluorine and two chlorine atoms on the pyridine ring, creating a highly electron-deficient heterocyclic scaffold. This combination enables selective coupling reactions in pharmaceutical synthesis, particularly in cross-coupling and nucleophilic aromatic substitution processes. The molecule exhibits enhanced reactivity and stability under standard conditions, making it a valuable building block for complex heterocyclic systems.
2,4-Dichloro-3-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling selective nucleophilic substitution reactions due to its orthogonal halogen reactivity. The fluorine atom at C3 facilitates directed metalation, while the dichloro substitution pattern supports sequential coupling strategies. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling make it ideal for constructing complex heterocyclic scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: