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CS-W001157 4
Total: USD 88.00

4-Morpholinophenol

  • CAS No. 6291-23-2

  • Cat. No. CS-0045039
  • Molecule weight179.22
  • Purity≥97%
  • MDL No.MFCD00066933

*For research and further manufacturing use only, not for direct human use.

4-Morpholinophenol|CS-0045039

Structure of 6291-23-2

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General Information

  • CAS No. 6291-23-2
  • Cat. No. CS-0045039
  • Purity ≥97%
  • MDL No. MFCD00066933
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃NO₂
  • Molecular Weight 179.22
  • Synonym(s) 4-(4-Morpholinyl)phenol
  • SMILES OC1=CC=C(N2CCOCC2)C=C1

Description

4-Morpholinophenol features a phenolic hydroxyl group conjugated with a morpholine ring, enabling dual functionality in synthetic intermediates. The electron-donating morpholine moiety enhances solubility and reactivity, while the aromatic scaffold supports facile derivatization. This compound serves as a key building block in medicinal chemistry and materials science applications.

Application

4-Morpholinophenol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and pharmaceutical intermediates. Its phenolic hydroxyl group facilitates direct functionalization or derivatization, while the morpholine moiety provides solubility enhancement and hydrogen-bonding capability. The compound exhibits good bench stability and is compatible with standard coupling and protection protocols, making it valuable for iterative synthesis workflows.

Synthesis

  • Route1
    • null|null
      110-91-8
    • null|null
      106-41-2
    • ~97%
    • In-stock
      4-Morpholinophenol|CS-0045039
      6291-23-2

    References

    • Reddy, Ch. Venkat; Kingston, Jesudoss V.; Verkade, John G. Journal of Organic Chemistry, 2008 , vol. 73, # 8 p. 3047 - 3062
  • Route2

    References

    • Yu, Chao-Wu; Chen, Grace S.; Huang, Chen-Wei; Chern, Ji-Wang Organic Letters, 2012 , vol. 14, # 14 p. 3688 - 3691
  • Route3
    • null|null
      110-91-8
    • null|null
      106-41-2
    • ~%
    • In-stock
      3-Morpholinophenol|CS-0044986
      27292-49-5
    • In-stock
      4-Morpholinophenol|CS-0045039
      6291-23-2

    References

    • Shi, Lei; Wang, Min; Fan, Chun-An; Zhang, Fu-Min; Tu, Yong-Qiang Organic Letters, 2003 , vol. 5, # 19 p. 3515 - 3517

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.7
  • LogP   1.2288
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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