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CS-W001157 4
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1-Pyridin-2-yl-propan-2-one

  • CAS No. 6302-02-9

  • Cat. No. CS-W008575
  • Molecule weight135.16
  • Purity≥95%
  • MDL No.MFCD00092717

*For research and further manufacturing use only, not for direct human use.

1-Pyridin-2-yl-propan-2-one|CS-W008575

Structure of 6302-02-9

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General Information

  • CAS No. 6302-02-9
  • Cat. No. CS-W008575
  • Purity ≥95%
  • MDL No. MFCD00092717
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO
  • Molecular Weight 135.16
  • Synonym(s) 1-(Pyridin-2-Yl)Propan-2-One
  • SMILES O=C(C)CC1=NC=CC=C1

Description

1-Pyridin-2-yl-propan-2-one features a conjugated ketone linked to a pyridine ring, enabling efficient integration into heterocyclic scaffolds. This bench-stable, moisture-tolerant compound serves as a key building block in medicinal chemistry, particularly for constructing bioactive molecules with enhanced solubility and metabolic stability.

Application

1-Pyridin-2-yl-propan-2-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of bioactive heterocycles. Its pyridyl ketone functionality facilitates nucleophilic addition, metal-catalyzed coupling, and enolization reactions under standard conditions. The tertiary α-keto group offers enhanced bench stability and simplifies purification, while tolerating common functional groups in complex molecule synthesis. This compound functions as a key intermediate in the development of kinase inhibitors and other pharmaceutical scaffolds.

Synthesis

  • Route1
    • null|null
      109-06-8
    • null|null
      75-05-8
    • ~61%
    • In-stock
      1-Pyridin-2-yl-propan-2-one|CS-W008575
      6302-02-9

    References

    • Graser, Markus; Kopacka, Holger; Wurst, Klaus; Mueller, Thomas; Bildstein, Benno Inorganica Chimica Acta, 2013 , vol. 401, p. 38 - 49
  • Route2
    • null|null
      109-06-8
    • ~%
    • In-stock
      1-Pyridin-2-yl-propan-2-one|CS-W008575
      6302-02-9

    References

    • US2002/107252 A1, ;
  • Route3
    • null|null
      1749-29-7
    • ~%
    • In-stock
      1-Pyridin-2-yl-propan-2-one|CS-W008575
      6302-02-9
    • null|null
      102315-71-9

    References

    • Journal of the American Chemical Society, , vol. 73, p. 4301 Journal of Pharmacy and Pharmacology, , vol. 7, p. 717,720

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.96
  • LogP   1.2131
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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