Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Methyl-1H-indole-3-carboxylic acid

  • CAS No. 63176-44-3

  • Cat. No. CS-0045040
  • Purity≥95%
  • MDL No.MFCD06203279

*For research and further manufacturing use only, not for direct human use.

2-Methyl-1H-indole-3-carboxylic acid|CS-0045040

Structure of 63176-44-3

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 63176-44-3
  • Cat. No. CS-0045040
  • Purity ≥95%
  • MDL No. MFCD06203279
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO₂
  • Molecular Weight 175.18
  • Synonym(s) 2-METHYLINDOLE-3-CARBOXYLIC ACID
  • SMILES O=C(C1=C(C)NC2=C1C=CC=C2)O

Description

2-Methyl-1H-indole-3-carboxylic acid features a sterically accessible indole core with a carboxylic acid group at the 3-position, enabling direct conjugation in bioconjugation and medicinal chemistry applications. This bench-stable scaffold integrates readily into peptide architectures and small-molecule libraries, offering enhanced solubility and metabolic stability compared to unsubstituted analogs.

Application

2-Methyl-1H-indole-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of indole-based scaffolds prevalent in bioactive molecules. Its carboxylic acid functionality facilitates direct coupling reactions, while the methyl group at the 2-position enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and is compatible with standard peptide coupling protocols, simplifying purification and integration into multi-step syntheses.

Synthesis

  • Route1
    • In-stock
      2-Methylindole|CS-W007556
      95-20-5
    • null|null
      124-38-9
    • ~81%
    • In-stock
      2-Methyl-1H-indole-3-carboxylic acid|CS-0045040
      63176-44-3

    References

    • Yoo, Woo-Jin; Capdevila, Montse Guiteras; Du, Xiangwei; Kobayashi, Shu Organic Letters, 2012 , vol. 14, # 20 p. 5326 - 5329,4
  • Route2

    References

    • Palomba, Michele; Pau, Amedeo; Boatto, Gianpiero; Asproni, Battistina; Auzzas, Luciana; Cerri, Riccardo; Arenare, Loredana; Filippelli, Walter; Falcone, Giuseppe; Motola, Giulia Archiv der Pharmazie, 2000 , vol. 333, # 1 p. 17 - 26
  • Route3

    References

    • Bioscience, Biotechnology and Biochemistry, , vol. 66, # 11 p. 2388 - 2394

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   53.09
  • LogP   2.17452
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Methyl-1H-indole-3-carboxylic acid sigma2-Methyl-1H-indole-3-carboxylic acid manufacturer2-Methyl-1H-indole-3-carboxylic acid price2-Methyl-1H-indole-3-carboxylic acid structure2-Methyl-1H-indole-3-carboxylic acid SDSbuy 2-Methyl-1H-indole-3-carboxylic acid2-Methyl-1H-indole-3-carboxylic acid supplier2-Methyl-1H-indole-3-carboxylic acid uses2-Methyl-1H-indole-3-carboxylic acid molecular weightprice of 2-Methyl-1H-indole-3-carboxylic acid2-Methyl-1H-indole-3-carboxylic acid chemical name formula of 2-Methyl-1H-indole-3-carboxylic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label