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Structure of 6324-50-1
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1,3,5-Trichloro-2-iodobenzene features a highly electron-deficient aromatic core stabilized by three chlorine atoms and a reactive iodine substituent. This configuration enables efficient coupling reactions in cross-coupling protocols, particularly in palladium-catalyzed transformations. The compound exhibits excellent bench stability and handles well under standard conditions, making it a reliable reagent for synthesizing complex aryl architectures.
1,3,5-Trichloro-2-iodobenzene serves as a versatile aryl halide building block in palladium-catalyzed cross-coupling reactions. The ortho-iodine enables efficient C–C bond formation via Suzuki, Stille, or Negishi coupling, while the three flanking chlorines provide steric and electronic modulation. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis of complex aromatic scaffolds in medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: