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Structure of 6327-97-5
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5-Bromo-1-methylpyrimidine-2,4(1h,3h)-dione features a brominated pyrimidinone core with enhanced electrophilicity at the C5 position. This bench-stable derivative integrates readily into cross-coupling reactions and serves as a key intermediate in medicinal chemistry. The methyl group stabilizes the enol tautomer, improving solubility and handling.
5-Bromo-1-methylpyrimidine-2,4(1H,3H)-dione serves as a versatile building block in medicinal chemistry, enabling efficient functionalization at the C5 position via palladium-catalyzed cross-coupling. Its methyl and carbonyl groups provide enhanced solubility and stability compared to unsubstituted analogs, while the bromine facilitates selective transformations under mild conditions. The pyrimidinedione core is compatible with standard synthetic workflows, offering predictable reactivity for constructing bioactive heterocycles and scaffold diversification.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: