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CS-W001157 4
Total: USD 88.00

4-Bromonaphthalene-1-sulfonyl chloride

  • CAS No. 63279-36-7

  • Cat. No. CS-0159376
  • Purity≥97%
  • MDL No.MFCD03424980

*For research and further manufacturing use only, not for direct human use.

4-Bromonaphthalene-1-sulfonyl chloride|CS-0159376

Structure of 63279-36-7

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General Information

  • CAS No. 63279-36-7
  • Cat. No. CS-0159376
  • Purity ≥97%
  • MDL No. MFCD03424980
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆BrClO₂S
  • Molecular Weight 305.58
  • Synonym(s) 4-bromo-1-naphthalenesulfonyl chloride
  • SMILES O=S(C1=C2C=CC=CC2=C(Br)C=C1)(Cl)=O

Description

4-Bromonaphthalene-1-sulfonyl chloride is a reactive sulfonyl chloride derivative featuring a brominated naphthalene core. This electrophilic reagent facilitates efficient coupling in sulfonamide synthesis, offering enhanced stability and selectivity under standard conditions.

Application

4-Bromonaphthalene-1-sulfonyl chloride serves as a versatile building block for sulfonamide synthesis, enabling efficient introduction of the naphthalene-sulfonamide motif into pharmaceutical and agrochemical scaffolds. Its brominated aryl moiety facilitates downstream cross-coupling reactions, while the sulfonyl chloride group offers high reactivity in nucleophilic substitution, ensuring reliable functionalization under mild conditions. The compound exhibits excellent bench stability and compatibility with diverse functional groups, making it ideal for multi-step synthetic sequences in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Halder, Amit Kumar; Adhikary, Nilanjan; Maity, Milan Kumar; Jha, Tarun European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 1760 - 1771

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P301+P330+P331-P363-P405-P501

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   3.5298
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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