Lot numbers can be found on the outside label of a product:
2,6-Difluoropyridin-4-amine
-
CAS No. 63489-58-7
- Cat. No. CS-W005329
- Purity≥95%
- MDL No.MFCD08436089
*For research and further manufacturing use only, not for direct human use.
Structure of 63489-58-7
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 63489-58-7
- Cat. No. CS-W005329
- Purity ≥95%
- MDL No. MFCD08436089
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₄F₂N₂
- Molecular Weight 130.10
- Synonym(s) 6-difluoropyridin-4-aMine
- SMILES NC1=CC(F)=NC(F)=C1
Description
2,6-Difluoropyridin-4-amine features a fluorinated pyridine core with strategically positioned electron-withdrawing substituents, enhancing its reactivity in cross-coupling and nucleophilic substitution processes. The para-amino group enables direct incorporation into pharmaceutical scaffolds, while the difluoro substitution imparts metabolic stability and improved membrane permeability. This bench-stable compound serves as a key building block for bioactive heterocycles.
Application
2,6-Difluoropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 4-position via nucleophilic substitution due to the activating effect of the fl uorine atoms. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient access to substituted pyridine scaffolds common in pharmaceutical development.
Synthesis
-
Route1
-
In-stock
2840-00-8 - ~32%
-
In-stock
63489-58-7
-
405230-78-6
References
-
Nucleosides, Nucleotides and Nucleic Acids, , vol. 20, # 12 p. 1975 - 2000
-
-
Route2
-
In-stock
2840-00-8
- ~94%
-
In-stock
63489-58-7
References
-
McNamara; Cook Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 340 - 347
-
-
Route3
-
1352830-73-9 - ~0%
-
1352830-76-2 -
In-stock
63489-58-7
References
-
BRACCO IMAGING S.P.A.; SWENSON, Rolf, E.; RAJU, Natarajan; ESTRELLA-JIMENEZ, Maria, E.; RAMALINGAM, Kondareddiar Patent: WO2011/159864 A1, 2011 ; Location in patent: Page/Page column 41-42 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS06
|
|
Signal Word : Danger
|
UN#: 2811
|
|
Class : 6.1
|
Packing Group : Ⅲ
|
|
Hazard Statements : H301-H311-H315-H319-H332-H335
|
|
|
Precautionary Statements : P264-P270-P330-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 38.91
- LogP 0.942
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 2,6-Difluoropyridin-4-amine sigma2,6-Difluoropyridin-4-amine manufacturer2,6-Difluoropyridin-4-amine price2,6-Difluoropyridin-4-amine structure2,6-Difluoropyridin-4-amine SDSbuy 2,6-Difluoropyridin-4-amine2,6-Difluoropyridin-4-amine supplier2,6-Difluoropyridin-4-amine uses2,6-Difluoropyridin-4-amine molecular weightprice of 2,6-Difluoropyridin-4-amine2,6-Difluoropyridin-4-amine chemical name formula of 2,6-Difluoropyridin-4-amine