2,6-Difluoropyridin-4-amine

Name: 2,6-Difluoropyridin-4-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 63489-58-7
Cat. No. CS-W005329
Purity≥95%
MDL No.MFCD08436089

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 63489-58-7

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Description

2,6-Difluoropyridin-4-amine features a fluorinated pyridine core with strategically positioned electron-withdrawing substituents, enhancing its reactivity in cross-coupling and nucleophilic substitution processes. The para-amino group enables direct incorporation into pharmaceutical scaffolds, while the difluoro substitution imparts metabolic stability and improved membrane permeability. This bench-stable compound serves as a key building block for bioactive heterocycles.

Application

2,6-Difluoropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 4-position via nucleophilic substitution due to the activating effect of the fl uorine atoms. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient access to substituted pyridine scaffolds common in pharmaceutical development.

General Information

CAS No. 63489-58-7
Cat. No. CS-W005329
Purity ≥95%
MDL No. MFCD08436089
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄F₂N₂
Molecular Weight 130.10
Synonym(s) 6-difluoropyridin-4-aMine
SMILES NC1=CC(F)=NC(F)=C1

Computational Chemistry Data

TPSA 38.91
LogP 0.942
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H311-H315-H319-H332-H335
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,6-Difluoropyridin-4-amine

CAS No. 63489-58-7

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