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CS-W001157 4
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o-Tolylhydrazine hydrochloride

  • CAS No. 635-26-7

  • Cat. No. CS-W007773
  • Purity≥98%
  • MDL No.MFCD00012925

*For research and further manufacturing use only, not for direct human use.

o-Tolylhydrazine hydrochloride|CS-W007773

Structure of 635-26-7

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General Information

  • CAS No. 635-26-7
  • Cat. No. CS-W007773
  • Purity ≥98%
  • MDL No. MFCD00012925
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁ClN₂
  • Molecular Weight 158.63
  • Synonym(s) o-tolylhydrazinium(1+) chloride; o-Tolylhydrazine hydrochloride
  • SMILES CC1=CC=CC=C1NN.Cl

Description

o-Tolylhydrazine hydrochloride offers a bench-stable, moisture-tolerant platform for constructing heterocyclic scaffolds. The ortho-methyl group enhances electron density at the hydrazine nitrogen, promoting reactivity in cycloaddition and condensation reactions. This derivative integrates readily into pharmaceutical intermediates and functional materials under standard conditions.

Application

o-Tolylhydrazine hydrochloride serves as a versatile building block in the synthesis of heterocyclic compounds, particularly pyrazoles and triazoles, through condensation and cyclization reactions. Its ortho-methyl group enhances electronic effects and steric control in downstream transformations. The hydrochloride salt ensures excellent bench stability, ease of handling, and compatibility with standard purification techniques, making it well-suited for medicinal chemistry and process-scale applications.

Synthesis

  • Route1
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    • ~%
    • In-stock
      o-Tolylhydrazine hydrochloride|CS-W007773
      635-26-7

    References

    • Journal of Heterocyclic Chemistry, , vol. 32, # 1 p. 1 - 11

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08,GHS09
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301+H311+H331-H317-H350-H410
Precautionary Statements : P261-P264-P270-P271-P272-P273-P280-P302+P352-P304+P340-P330-P361+P364-P362+P364-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   1.70242
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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