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NMDA

  • CAS No. 6384-92-5

  • Cat. No. CS-2194
  • Molecule weight147.13
  • Purity≥98%
  • MDL No.MFCD00004226

*For research and further manufacturing use only, not for direct human use.

NMDA|CS-2194

Structure of 6384-92-5

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General Information

  • CAS No. 6384-92-5
  • Cat. No. CS-2194
  • Purity ≥98%
  • MDL No. MFCD00004226
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₄
  • Molecular Weight 147.13
  • Synonym(s) N-Methyl-D-aspartic acid
  • SMILES O=C(O)C[C@H](C(O)=O)NC

Description

N-Methyl-D-aspartic acid, Hydrate (CAS 6384-92-5) is synthesized via S-adenosylmethionine-dependent methylation of D-aspartate in neuroendocrine tissues, where it modulates glutamatergic signaling at NMDA receptor complexes with nanomolar potency.

Application

N-Methyl-D-aspartic Acid, Hydrate (CAS 6384-92-5) induces NMDA receptor-mediated excitotoxicity in retinal cell cultures by overactivating glutamate signaling pathways. This triggers calcium influx and neuronal degeneration. Researchers use this setup to model neurodegenerative processes and test protective compounds in vitro.

Synthesis

  • Route1

    References

    • Helvetica Chimica Acta, , vol. 45, p. 2005 - 2011
  • Route2
    • null|null
      144300-47-0
    • ~%
    • In-stock
      NMDA|CS-2194
      6384-92-5

    References

    • Helvetica Chimica Acta, , vol. 45, p. 2005 - 2011
  • Route3
    • null|null
      89464-62-0
    • ~%
    • In-stock
      NMDA|CS-2194
      6384-92-5

    References

    • Helvetica Chimica Acta, , vol. 45, p. 2005 - 2011

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   86.63
  • LogP   -0.8663
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   4

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