N-Methoxy-N,2,2-trimethylpropanamide

Name: N-Methoxy-N,2,2-trimethylpropanamide
Brand: ChemScene
Availability: InStock
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CAS No. 64214-60-4
Cat. No. CS-0123045
Purity≥98%
MDL No.MFCD11847426

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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N-Methoxy-N,2,2-trimethylpropanamide|CS-0123045

Structure of 64214-60-4

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Description

N-Methoxy-N,2,2-trimethylpropanamide features a sterically hindered amide scaffold that enhances stability and facilitates selective reactivity in synthetic transformations. This bench-stable reagent integrates efficiently into coupling protocols, enabling reliable amide bond formation under standard conditions.

Application

N-Methoxy-N,2,2-trimethylpropanamide serves as a robust amide surrogate in synthetic workflows, enabling efficient formation of ketones via the modified Nef reaction. Its trimethyl-substituted backbone enhances bench stability and simplifies purification, while the methoxy group facilitates selective hydrolysis under mild conditions. This reagent functions effectively in the synthesis of carbonyl intermediates and provides excellent functional group tolerance in complex molecule assembly.

General Information

CAS No. 64214-60-4
Cat. No. CS-0123045
Purity ≥98%
MDL No. MFCD11847426
Storage RT, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₅NO₂
Molecular Weight 145.20
Synonym(s) Propanamide, N-methoxy-N,2,2-trimethyl-
SMILES CC(C)(C)C(N(OC)C)=O

Computational Chemistry Data

TPSA 29.54
LogP 1.0523
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Other Classifications

Building Blocks Skeleton Fatty chain compounds

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N-Methoxy-N,2,2-trimethylpropanamide

CAS No. 64214-60-4

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