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CS-W001157 4
Total: USD 88.00

1,2-Difluoro-3-iodobenzene

  • CAS No. 64248-57-3

  • Cat. No. CS-0109508
  • Purity≥98%
  • MDL No.MFCD08458090
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1,2-Difluoro-3-iodobenzene|CS-0109508

Structure of 64248-57-3

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Description

1,2-Difluoro-3-iodobenzene is a fluorinated aromatic building block featuring ortho-fluorine and meta-iodine substituents on a benzene ring. This configuration enables selective cross-coupling reactions under palladium catalysis, leveraging the iodine moiety as a reactive handle. The electron-withdrawing fluorine groups enhance stability and modulate reactivity, facilitating efficient functionalization in complex molecule synthesis.

Application

1,2-Difluoro-3-iodobenzene serves as a versatile building block in cross-coupling chemistry, enabling the construction of fluorinated biaryls and heterocycles under palladium-catalyzed conditions. The ortho-fluoro substituents enhance regioselectivity in subsequent functionalizations, while the iodine moiety provides high reactivity in Suzuki, Stille, and Negishi couplings. Bench-stable and readily purified by column chromatography, it functions as a key intermediate in the synthesis of pharmaceutical scaffolds and agrochemicals requiring controlled fluorination patterns.

General Information

  • CAS No. 64248-57-3
  • Cat. No. CS-0109508
  • Purity ≥98%
  • MDL No. MFCD08458090
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃F₂I
  • Molecular Weight 239.99
  • Synonym(s) None
  • SMILES IC1=C(F)C(F)=CC=C1

Computational Chemistry Data

  • TPSA   0
  • LogP   2.5694
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS08
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H304
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P331-P370+P378-P405-P501

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