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CS-W001157 4
Total: USD 88.00

(2S,4S)-pyrrolidine-2,4-dicarboxylic acid

  • CAS No. 64927-38-4

  • Cat. No. CS-M0777
  • Purity≥95%
  • MDL No.MFCD00274448

*For research and further manufacturing use only, not for direct human use.

(2S,4S)-pyrrolidine-2,4-dicarboxylic acid|CS-M0777

Structure of 64927-38-4

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General Information

  • CAS No. 64927-38-4
  • Cat. No. CS-M0777
  • Purity ≥95%
  • MDL No. MFCD00274448
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉NO₄
  • Molecular Weight 159.14
  • Synonym(s) L-CIS-PYRROLIDINE-2,4-DICARBOXYLIC ACID
  • SMILES O=C(O)[C@H]1C[C@H](NC1)C(O)=O

Description

(2S,4S)-pyrrolidine-2,4-dicarboxylic acid is a stereochemically defined cyclic diacid featuring two carboxyl groups at the 2- and 4-positions of a pyrrolidine ring. This configuration imparts high structural rigidity and precise spatial orientation, making it an effective scaffold for probing receptor-ligand interactions in neurochemical studies. The molecule exhibits favorable solubility in aqueous buffers and stability under standard bench conditions, enabling straightforward integration into biochemical assays and medicinal chemistry campaigns.

Application

(2S,4S)-Pyrrolidine-2,4-dicarboxylic acid serves as a stereochemically defined building block for the synthesis of bioactive heterocycles and peptidomimetics. Its rigid, enantiopure scaffold enables precise control over molecular conformation in medicinal chemistry campaigns. The molecule exhibits excellent bench stability and facilitates efficient coupling reactions with minimal racemization, making it suitable for both small-molecule library construction and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   86.63
  • LogP   -0.8663
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   2

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