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Structure of 651027-00-8
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4-Bromo-3,5-difluorobenzoic acid features a trifunctional aromatic core with complementary halogen and carboxylic acid handles. The electron-deficient ring enables efficient cross-coupling, while the ortho-fluorine substituents enhance metabolic stability. This robust scaffold integrates readily into bioactive molecules and serves as a key intermediate in medicinal chemistry and materials synthesis under standard conditions.
4-Bromo-3,5-difluorobenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient incorporation of halogenated aromatic scaffolds. Its orthogonal reactivity profile—combining bromine for cross-coupling and fluorines for modulating electronic properties—facilitates downstream functionalization via Pd-catalyzed reactions. The carboxylic acid group supports direct derivatization or amide formation, while the molecule exhibits excellent bench stability and ease of purification, making it well-suited for scalable process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: