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CS-W001157 4
Total: USD 88.00

6-Formylnicotinic acid

  • CAS No. 6542-47-8

  • Cat. No. CS-0454615
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Formylnicotinic acid|CS-0454615

Structure of 6542-47-8

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General Information

  • CAS No. 6542-47-8
  • Cat. No. CS-0454615
  • Purity ≥98%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅NO₃
  • Molecular Weight 151.12
  • Synonym(s) Nicotinic acid, 6-formyl- (8CI)
  • SMILES C1=CC(=NC=C1C(=O)O)C=O

Description

6-Formylnicotinic acid is a bench-stable, moisture-tolerant pyridine derivative bearing a formyl group at the 6-position and a carboxylic acid at the 3-position. This dual functionality enables direct coupling in peptide synthesis or conjugation strategies, where the aldehyde facilitates oxime ligation and the acid supports amide bond formation.

Application

6-Formylnicotinic acid serves as a versatile building block for heterocyclic synthesis, enabling direct access to pyridine-based scaffolds via cyclization and functionalization reactions. Its ortho-formyl and carboxylic acid groups offer complementary reactivity for sequential transformations, facilitating the construction of medicinally relevant frameworks. The compound exhibits good bench stability and is readily purified by recrystallization, supporting reliable use in iterative synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.26
  • LogP   0.5923
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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