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CS-W001157 4
Total: USD 88.00

2,5-Difluoroterephthalic acid

  • CAS No. 655-14-1

  • Cat. No. CS-0163371
  • Molecule weight202.11
  • Purity≥95%
  • MDL No.MFCD00042502

*For research and further manufacturing use only, not for direct human use.

2,5-Difluoroterephthalic acid|CS-0163371

Structure of 655-14-1

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General Information

  • CAS No. 655-14-1
  • Cat. No. CS-0163371
  • Purity ≥95%
  • MDL No. MFCD00042502
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄F₂O₄
  • Molecular Weight 202.11
  • Synonym(s) 1,4-Benzenedicarboxylicacid,2,5-difluoro
  • SMILES O=C(O)C1=CC(F)=C(C=C1F)C(=O)O

Description

2,5-Difluoroterephthalic acid features a rigid aromatic core with two fluorine substituents positioned at the 2 and 5 ring positions, imparting enhanced electron-withdrawing character and improved solubility in polar solvents. This structural motif enables efficient integration into metal-organic frameworks and functional polymers, where its defined geometry supports precise network assembly under standard conditions.

Application

2,5-Difluoroterephthalic acid serves as a valuable building block for the synthesis of fluorinated aromatic polymers and bioactive heterocycles. Its two carboxylic acid groups enable straightforward amide, ester, and imide formation, while the ortho-fluoro substituents offer enhanced electrophilicity for subsequent nucleophilic aromatic substitution. The compound exhibits good bench stability and facilitates purification via recrystallization, making it well-suited for scalable synthetic applications in medicinal chemistry and materials science.

Synthesis

  • Route1
    • 1,4-Bis(bromomethyl)-2,5-difluorobenzene|CS-0876320
      35335-08-1
    • ~78%
    • In-stock
      2,5-Difluoroterephthalic acid|CS-0163371
      655-14-1

    References

    • Huang, Xiao-Song; Qing, Feng-Ling Journal of Fluorine Chemistry, 2008 , vol. 129, # 11 p. 1076 - 1082
  • Route2
    • null|null
      651-89-8
    • ~%
    • In-stock
      2,5-Difluoroterephthalic acid|CS-0163371
      655-14-1

    References

    • Aroskar,E.V. et al. Journal of the Chemical Society, 1964 , p. 2975 - 2981
  • Route3
    • null|null
      3827-85-8
    • ~%
    • In-stock
      2,5-Difluoroterephthalic acid|CS-0163371
      655-14-1

    References

    • Aroskar,E.V. et al. Journal of the Chemical Society, 1964 , p. 2975 - 2981

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   74.6
  • LogP   1.3612
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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