2,2-Difluorobenzo[d][1,3]dioxole-5-carbaldehyde

Name: 2,2-Difluorobenzo[d][1,3]dioxole-5-carbaldehyde
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 656-42-8
Cat. No. CS-W016922
Purity≥98%
MDL No.MFCD00792420

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2,2-Difluorobenzo[d][1,3]dioxole-5-carbaldehyde|CS-W016922

Structure of 656-42-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 656-42-8
Cat. No. CS-W016922
Purity ≥98%
MDL No. MFCD00792420
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₄F₂O₃
Molecular Weight 186.11
Synonym(s) 5-FORMYL-2,2-DIFLUOROBENZODIOXOLE
SMILES O=CC1=CC=C(OC(F)(F)O2)C2=C1

Description

2,2-Difluorobenzo[d][1,3]dioxole-5-carbaldehyde features a rigid, electron-deficient aromatic core paired with a highly reactive aldehyde group. This configuration enables direct integration into complex heterocycles and facilitates efficient coupling in transition-metal-catalyzed transformations. The difluorinated ring enhances metabolic stability and modulates electronic properties for applications in medicinal chemistry and advanced materials synthesis.

Application

2,2-Difluorobenzo[d][1,3]dioxole-5-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluorinated aromatic core with orthogonal reactivity. The aldehyde group facilitates efficient coupling reactions, while the 1,3-dioxole ring enhances metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with standard functional group transformations make it ideal for rapid scaffold diversification in API development.

Synthesis

Route1
- In-stock
  
  33070-32-5
- 68-12-2
- ~%
- In-stock
  
  656-42-8
References
- US2007/37815 A1, ; Page/Page column 20 ;
Route2
- 1269252-03-0
- ~95%
- In-stock
  
  656-42-8
References
- Hagooly, Youlia; Welch, Michael J.; Rozen, Shlomo Organic and Biomolecular Chemistry, 2011 , vol. 9, # 3 p. 902 - 905
Route3
- 149045-78-3
- 100-97-0
- ~%
- In-stock
  
  656-42-8
References
- US5420308 A1, ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 35.53
LogP 1.8206
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Benzodioxolane compounds

Key Words

656-42-8 sigma656-42-8 manufacturer656-42-8 price656-42-8 structure656-42-8 SDSbuy 656-42-8656-42-8 supplier656-42-8 uses656-42-8 molecular weightprice of 656-42-8656-42-8 chemical name formula of 656-42-8

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2,2-Difluorobenzo[d][1,3]dioxole-5-carbaldehyde

CAS No. 656-42-8

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words